Use of 9-Valent human papillomavirus (HPV) vaccine: Updated HPV vaccination recommendations of the Advisory Committee on Immunization Practices, Monitoring the safety of quadrivalent human papillomavirus vaccine: findings from the Vaccine Safety Datalink, Postlicensure safety surveillance for quadrivalent human papillomavirus recombinant vaccine, Human papillomavirus vaccination coverage among adolescent girls 2007-2012, and post-licensure vaccine safety monitoring 2006-2013-United States. The patients who developed blood clots had known risk factors for developing them, such as taking oral contraceptives. Efficacy of a bivalent HPV 16/18 vaccine against anal HPV 16/18 infection among young women: A nested analysis within the Costa Rica Vaccine Trial. HPV vaccination in this age range provides less benefit. More information is available at or by telephone at 1–800–293–3881. "Product Information. In the United States, only about half of all adolescents get the full course of HPV shots, according to the C.D.C., although the numbers are slowly rising. Some Medicare Advantage plans cover dental services. Emily is one of the thousands of teenage girls who have reported feeling seriously unwell following the routine vaccination since the immunisation programme was introduced in 2007. Severe allergic reactions following vaccination are rare, but can be life threatening. Cervarix (human papillomavirus vaccine)." Naleway AL, Crane B, Smith N et al. Case-centered analysis of Optic Neuritis following vaccines. It is approved for use in children at age 9. CDC uses 3 systems to monitor vaccine safety: Donahue JG, Kieke BA, Lewis EM, et al. Postlicensure safety surveillance for quadrivalent human papillomavirus recombinant vaccine. Cervarix, Gardasil 9, human papillomavirus vaccine, View Human papillomavirus vaccine reviews. Most private insurance plans cover HPV vaccination. Yang A, Farmer E, Wu TC, Hung CF. A safety review by the FDA and the CDC considered adverse side effects related to Gardasil immunization that have been reported to the Vaccine Adverse Events Reporting System since the vaccine was licensed (19–21). 2016 Jun 2; 12(6): 1406-17. Baxter R, Lewis E, Fireman B, DeStefano F, Gee J, Klein NP. Postlicensure safety surveillance for quadrivalent human papillomavirus recombinant vaccineexternal icon. MMWR Morb Mortal Wkly Rep. 2013 Jul 26; 62(29): 591-595. MMWR Morbidity and Mortality Weekly Report 2019; 68(32):698–702. Anxiety. If you would like to reproduce some or all of this content, see Reuse of NCI Information for guidance about copyright and permissions. Naud PS, Roteli-Martins CM, De Carvalho NS, et al. They can tell you more about the vaccine and advise you on whether it’s right for you or your child. HPV 9-valent vaccine is used in girls and young women ages 9 through 45 to prevent cervical/vaginal/anal cancers or genital warts caused by certain types of HPV. General Practitioner Attendance in Proximity to HPV Vaccination: A Nationwide, Register-Based, Matched Case-Control Study. Since 2016, the only vaccine that’s used in the U.S. is Gardasil 9. Effect of human papillomavirus 16/18 L1 viruslike particle vaccine among young women with preexisting infection: A randomized trial. bleeding gums. What research is being done on strategies to prevent HPV infection? Naleway AL, Gold R, Drew L, et al. Vaccines against the human papillomavirus have sharply reduced infections, genital and anal warts, and precancerous lesions in young women and girls in more than a dozen wealthy countries, a major new study has found — powerful evidence that these vaccines will ultimately cause major drops in cervical cancer. The current HPV vaccines are based on virus-like particles (VLPs) that are formed by HPV surface components. The current ACIP (CDC) recommendations for HPV vaccination are as follows (4): The HPV vaccine is given as a series of shots. If such reactions occur, call 9-1-1 and get the person to the nearest hospital. 2011 Oct 26; 29(46): 8279-84. Herrero R, Quint W, Hildesheim A, et al. ACIP specifies different dosing schedules, depending on the age of the individual (5). provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Vaccine. HPV is a group of more than 200 related viruses, of which more than 40 are spread through direct sexual … This ensures that they’re protected against HPV before they’re likely to have exposure to the virus. Although HPV vaccines have been found to be safe when given to people who are already infected with HPV, the vaccines do not treat infection. Stokley S, Curtis CR, Jeyarajah J, Harrington T, Gee J, Markowitz L.  Human papillomavirus vaccination coverage among adolescent girls 2007-2012, and post-licensure vaccine safety monitoring 2006-2013-United Statesexternal icon. Mild to moderate side effects occur more often but are still uncommon. Epub 2016 Mar 30. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Sociodemographic and clinical correlates of human papillomavirus vaccine attitudes and receipt among Wisconsin adolescentsexternal icon. On Wednesday, a C.D.C. NLM Landazabal CS, Moro PL, Lewis P, Omer SB. 2019 Mar 28; 37(14): 1938-1944. More important, precancerous cervical lesions declined by 51 percent among teenage girls who were screened, and by 31 percent among screened women up to age 24. The research, published on Thursday in the Lancet, analyzed dozens of studies that, when combined, included 66 million females and males below the age of 30 living in 14 wealthy countries where HPV vaccines were introduced as early as 2007. Available for Android and iOS devices. The efficacy and safety of Tipapkinogen Sovacivec therapeutic HPV vaccine in cervical intraepithelial neoplasia grades 2 and 3: Randomized controlled phase II trial with 2.5 years of follow-up. There are more than 100 strains of HPV, and virtually every sexually active adult becomes at least temporarily infected with some of them, experts say. "Product Information. CDC recommends HPV vaccination for everyone through age 26 years, if not vaccinated already. Not only does vaccination protect vaccinated individuals against infection by the HPV types targeted by the respective vaccine, but also vaccination of a significant proportion of the population can reduce the prevalence of the vaccine-targeted HPV types in the population, thereby providing some protection for individuals who are not vaccinated (a phenomenon called herd immunity). These problems are similar to those commonly experienced with other vaccines. 2020 Sep 8;12:929-939. doi: 10.2147/CLEP.S253429. McCarthy NL, Gee J, Sukumaran L et al. A 12-year follow-up on the long-term effectiveness of the quadrivalent human papillomavirus vaccine in 4 Nordic countries. In the trials that led to the approval of Gardasil and Cervarix, these vaccines were found to provide nearly 100% protection against persistent cervical infections with HPV types 16 and 18 and the cervical cell changes that these persistent infections can cause. Overall, these are the major pros of the HPV vaccine: It can protect against cancer and genital warts. While it cannot eliminate strains of the virus that have already been caught, evidence heard by the committee indicated that the vaccine could, for example, protect a divorced or widowed woman who has had very few sexual partners but is beginning to date again. Three vaccines that prevent infection with disease-causing HPV types are licensed for use in the United States: Gardasil®, Gardasil® 9, and Cervarix®. Kavanagh K, Pollock KG, Cuschieri K, et al. Drolet M, Bénard É, Pérez N, Brisson M; HPV Vaccination Impact Study Group. Primary Ovarian Insufficiency and Adolescent Vaccination. Gardasil also prevents infection with HPV types 6 and 11, which cause 90% of genital warts (3). Human papillomavirus (HPV) Most HPV infections go away without the need for treatment. A randomized clinical trial is currently under way in Costa Rica to evaluate if a single dose of HPV vaccine is sufficient to protect against HPV infection (29, 30). The HPV vaccine can cause side effects. Vaccine 2018 Jan 20. pii: S0264-410X(18)30018-5. Some side effects may not be reported. Gold R, Naleway A, Riedlinger K. Factors predicting completion of the human papillomavirus vaccine seriesexternal icon. How Does TRICARE for Life Work with Medicare? Epub 2018 Aug 21. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: The most common adverse events were injection site reactions, fatigue, headache, and myalgia. Pediatr. 2019 Jun 3;6(6):75. doi: 10.3390/children6060075. Each one involves a series of two or three injections into a muscle over six months, depending on age. Conclusion: Human Papillomavirus Vaccine Coverage and Prevalence of Missed Opportunities for Vaccination in an Integrated Healthcare Systemexternal icon. In countries where it has long been available, the vaccine has greatly reduced the incidence of precancerous lesions and genital warts. Gynecol. Which adverse events are considered “serious”? Unmasking of conditions at vaccination visits is a plausible explanation for the increased risk associated with qHPV in this study because coeliac disease is underdiagnosed in Scandinavian populations. Chaturvedi AK, Engels EA, Pfeiffer RM, et al. Symptoms of a severe allergic reaction can include hives, swelling of the face and throat, difficulty breathing, a fast heartbeat, dizziness, and weakness. Everything you Need to Know About Human Papillomavirus Infection, Human Papillomavirus (HPV) and Cervical Cancer, Common Types of Human Papillomavirus (HPV), Human Papillomavirus (HPV) of the Mouth: What You Should Know, Testing for HPV Can Be Difficult — But Conversations About It Shouldn’t Be. Maternal and Infant Outcomes After Human Papillomavirus Vaccination in the Periconceptional Period or During Pregnancyexternal icon. Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2/3: a randomised, double-blind, placebo-controlled phase 2b trial. If a single dose of HPV vaccine were effective, that would be an important advance. 2019 May 25; 8: 1001568. 2015 Jan 6;313(1):54-61. doi: 10.1001/jama.2014.16946. Gardasil (human papillomavirus vaccine)." 2015; 64(11):300-304. However, these are rare. Klein NP, Goddard K, Lewis E, Ross P, Gee J, DeStefano F, Baxter R. Long term risk of developing type 1 diabetes after HPV vaccination in males and femalesexternal icon. Vaccine. J Adolesc Health. The team — comprising researchers in Canada, the United States, Australia and Europe — found that in countries where the vaccine had been distributed for more than five years, the two strains of human papillomavirus that cause 70 percent of cancers — HPV 16 and 18 — had decreased by 83 percent among teenage girls and by 66 percent among women aged 20 to 24. New England Journal of Medicine 2006; 354(11):1109–1112. Medicaid covers HPV vaccination in accordance with ACIP recommendations, and immunizations are a mandatory service under Medicaid for eligible individuals under age 21. Human papillomavirus vaccination: Recommendations of the Advisory Committee on Immunization Practices (ACIP). Our syndication services page shows you how. The newest HPV vaccine is Gardasil 9, which protects against the nine most dangerous strains. Human papillomavirus vaccines: WHO position paper, May 2017-Recommendations. Clipboard, Search History, and several other advanced features are temporarily unavailable. [Pediatrics 2019], Human Papillomavirus Vaccination: Recommendations of the Advisory Committee on Immunization Practices (ACIP). The W.H.O. The most common side effects are usually mild, like a sore arm from the shot. Vaccine 2011; 29(46):8279-8284. Near Real-Time Surveillance to Assess the Safety of the 9-valent Human Papillomavirus Vaccine.  |  Addressing HPV vaccine myths: practical information for healthcare providers. A controlled trial of a human papillomavirus type 16 vaccine. Human papillomavirus and rising oropharyngeal cancer incidence in the United States. Annual Report to the Nation on the Status of Cancer, 1975-2009, featuring the burden and trends in human papillomavirus (HPV)-associated cancers and HPV vaccination coverage levels.  |  More information about contraindications and precautions. Warts fell by half among teenage boys, and by a third among young men up to age 24. Jemal A, Simard EP, Dorell C, et al. doi: 10.1016/j.vaccine.2012.05.039. However, the HPV vaccine can help prevent cervical cancer in women if … Falls after fainting may sometimes cause serious injuries, such as head injuries. Hildesheim A, Gonzalez P, Kreimer AR, et al. 2020 Jun 5;8(2):278. doi: 10.3390/vaccines8020278. Pediatrics. Sustained efficacy, immunogenicity, and safety of the HPV-16/18 AS04-adjuvanted vaccine: Final analysis of a long-term follow-up study up to 9.4 years post-vaccination. Medicare and Oral Surgery: What Is Covered? You can get the vaccine until age 45. Impact of human papillomavirus (HPV) 16 and 18 vaccination on prevalent infections and rates of cervical lesions after excisional treatment. ACIP recommends that women who have an HPV infection and/or an abnormal Pap test result that may indicate an HPV infection should still receive HPV vaccination if they are in the appropriate age group because the vaccine may protect them against high-risk HPV types that they have not yet acquired. Quadrivalent HPV vaccine safety review and safety monitoring plans for nine-valent HPV vaccine in the United States. 2019 Dec;144(6);e20191791. The Lancet. Another prevention strategy that is being explored is topical microbicides. Saving Lives, Protecting People, Frequently Asked Questions about HPV Vaccine Safety, HPV Vaccine – ACIP Recommendations and Guidance, Vaccine Adverse Event Reporting System (VAERS), Safety of the 9-Valent Human Papillomavirus Vaccine. Lancet 2017; 390(10108):2143-2159. Last updated on Jul 22, 2020. Because it can take many years for an HPV infection to progress to cancer, the study was the first to measure precancerous lesions. For more information, see Report an Adverse Event to VAERSexternal icon. J Gen Intern Med. HPV Vaccine Proves Its Mettle Against Cervical Cancer, HPV Vaccination Rises Among U.S. Child and Adult Immunization Schedules That analysis showed that, up to 8 years after the start of vaccination, diagnoses of anogenital warts decreased by 31% among women aged 25–29 years, by 48% among boys aged 15–19 years, and by 32% among men aged 20–24 years, compared with the period before vaccination began. Epub 2017 Sep 19. Because HPV vaccines do not protect against all HPV types that can cause cancer, women who have been vaccinated are advised to follow the same screening recommendations as unvaccinated women. Uptake, coverage, and completion of quadrivalent human papillomavirus vaccine in the Vaccine Safety Datalink, July 2006-June 2011external icon. Epub 2015 Nov 6. [Article in French] Fischer A(1). The best way to know how much vaccination will cost is to contact the insurance plan or the clinic. Ten Years of Human Papillomavirus Vaccination in the United States. It suggests that the vaccine be given while the recipient is sitting or lying down, and that he or she be watched for 15 minutes afterward. 4. About 100 countries around the world now recommend HPV vaccination, at least for girls. Reports of swelling and redness also increased with each following dose for those receiving Gardasil 9. Healthcare providers and vaccine manufacturers are required by law to report certain adverse events following vaccination to VAERS; patients and caregivers can also submit reports. Why is it important for people to follow HPV vaccination recommendations? However, these women should be told that the vaccination will not cure them of current HPV infections or treat the abnormal results of their Pap test (23). Methods: In the United States, for example, the Centers for Disease Control and Prevention recommends it for all males and females starting at age 11 and up to age 26. pii: dju436. Acad. Human papillomavirus vaccination coverage among adolescents, 2007-2013, and postlicensure vaccine safety monitoring, 2006-2014--United States. For example, compared with the period before vaccination began. Merck & Company Inc, Whitehouse Station, NJ. BMC Infectious Diseases 2013; 13:140. Human papillomavirus vaccination: recommendations of the Advisory Committee on Immunization Practices (ACIP). 2013 Oct 9;347:f5906. HPV vaccine is safe and effective at preventing HPV-related infections and cancers. 2020 Sep;35(9):2647-2654. doi: 10.1007/s11606-020-05845-8. In addition, the rates of HPV infection remain low for at least 7 years (27). 2.3K likes. | Sign up for the Science Times newsletter.]. Gee J, Naleway A, Shui I et al. Vaccine. People should not get HPV vaccine if they: HPV vaccine is not recommended for pregnant women. The next generation of HPV vaccines: Nonavalent vaccine V503 on the horizon. Only a handful cause cancer or warts. currently recommends that all girls aged 9 to 14 get the HPV vaccine, but wealthier countries often offer it to both boys and girls, and in a wider range of ages. Do women who have been vaccinated still need to be screened for cervical cancer? It often has few or no symptoms, which is why getting…, While testing for HPV can be difficult, the conversations around this topic don’t have to be. Epub 2019 Nov 18. HHS Primary Ovarian Insufficiency and Adolescent Vaccination. VanWormer JJ, Bendixsen CG, Vickers ER et al. Sampson JN, Hildesheim A, Herrero R, et al. BMC Public Health. A safety review of Gardasil in Denmark and Sweden did not identify an increased risk of blood clots (20). Epub 2014 Dec 8. The Vaccine Adverse Event Reporting System (VAERS) is an early warning system, co-managed by CDC and FDA, that monitors for potential vaccine safety problems. To receive email updates about this page, enter your email address: Centers for Disease Control and Prevention. In a 2017 position paper, the World Health Organization stated that the HPV vaccines have equivalent efficacy (7). Evidence for single-dose protection by the bivalent HPV vaccine-Review of the Costa Rica HPV vaccine trial and future research studies. Meites E, Szilagyi PG, Chesson HW, et al. An analysis of data from a community-based clinical trial of Cervarix in Costa Rica, where cervical cancer rates are high, found than even one dose of the vaccine caused the body to produce approximately nine times more antibodies against HPV than the body produces in response to a natural HPV infection, and those antibody levels persisted for at least 7 years (26). Magnan S, Tota JE, El-Zein M, et al. Want to use this content on your website or other digital platform? In addition, the federal Vaccines for Children Program provides immunization services for children 18 and under who are Medicaid eligible, uninsured, underinsured, receiving immunizations through a Federally Qualified Health Center or Rural Health Clinic, or are Native American or Alaska Native. Vaccine. "Product Information. 2019 Feb 21; 37(9): 1229-1234. Absence of venous thromboembolism risk following quadrivalent human papillomavirus vaccination, Vaccine Safety Datalink, 2008-2011external icon. The vaccines are so effective that when given to enough young girls, they also give partial protection to both unvaccinated girls and boys, simply because fewer people in sexual networks are carrying the virus, commonly called HPV. Background: A clinical trial of Gardasil in men indicated that it can prevent anal cell changes caused by persistent infection and genital warts (13). Vaccinations and Immune Response in Celiac Disease. They can answer questions and offer advice based on your specific health needs. Whilst safety studies have been reassuring, focus has been on the primary target group, the young adolescent girls. A woman receives the HPV vaccine in Shanghai. In addition, the vaccines may reduce the need for screening and subsequent medical care, biopsies, and invasive procedures associated with follow-up from abnormal cervical screening, thus helping to reduce health care costs and anxieties related to follow-up procedures (17). 2017 Oct 2; 17(1): 766. If you need cataract surgery, Medicare may cover most of the cost. Gardasil 9 is as effective as Gardasil for the prevention of diseases caused by the four shared HPV types (6, 11, 16, and 18), based on similar antibody responses in participants in clinical studies. Markowitz LE, Tsu V, Deeks SL, Cubie H, Wang SA, Vicari AS, Brotherton JM. Gardasil 9 (human papillomavirus 9-valent vaccine, recombinant; 9vHPV) was approved by FDA for use in 2014. Slade BA, Leidel L, Vellozzi C, Woo EJ, Hua W, Sutherland A, et al. Gardasil 9 [PDF – 25 pages]external icon: The Food and Drug Administration (FDA) approved this vaccine in 2014. The human papillomavirus (HPV) affects nearly 80 million people in the United States. To date, no serious side effects have been shown to be caused by the vaccines. The safety of Gardasil 9 was studied in clinical trials with more than 15,000 participants before it was licensed and continues to be monitored. Ongoing clinical trials are testing the safety and efficacy of a therapeutic DNA vaccine to treat HPV-related cervical and vulvar lesions. HPV is a common sexually transmitted infection that can cause problems from genital warts to cancer. Subscribe to newsletters for the latest medication news, alerts, new drug approvals and more. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. In the case of permitted digital reproduction, please credit the National Cancer Institute as the source and link to the original NCI product using the original product's title; e.g., “Human Papillomavirus (HPV) Vaccines was originally published by the National Cancer Institute.”. It is important that as many people as possible in the recommended age group get vaccinated. We used Poisson regression to estimate RRs according to qHPV vaccination status with two-sided 95% confidence intervals (95% CIs). What is human papillomavirus (HPV) 9-valent vaccine? Pellegrino P, Carnovale C, Pozzi M, Antoniazzi S, Perrone V, Salvati D, Gentili M, Brusadelli T, Clementi E, Radice S. Autoimmun Rev. Whilst safety studies have been reassuring, focus has been on the primary target group, the … If a problem is found with a vaccine, CDC and FDA will inform health officials, health care providers, and the public. Epub 2014 Jan 24. New England Journal of Medicine 2011; 364(5):401-411. The Centers for Disease Control and Prevention (CDC) recommends that preteens receive the vaccine at around age 11 or 12 years old. For more information, see Who should get HPV Vaccine. Yes. Efficacy of a carrageenan gel against transmission of cervical HPV (CATCH): Interim analysis of a randomized, double-blind, placebo-controlled, phase 2B trial. American Journal of Obstetrics and Gynecology 2016; 215(2):212.e1-212.e15. These vaccines are Gardasil, Gardasil 9, and Cervarix. Epub 2018 Sep 21. Factors predicting completion of the human papillomavirus vaccine series, Uptake, coverage, and completion of quadrivalent human papillomavirus vaccine in the Vaccine Safety Datalink, July 2006-June 2011, Monitoring the safety of quadrivalent human papillomavirus vaccine: Findings from the Vaccine Safety Datalink. Journal of the National Cancer Institute 2018; 110(2). Post-licensure safety monitoring of quadrivalent human papillomavirus vaccine in the Vaccine Adverse Event Reporting System (VAERS), 2009-2015, Reports of Postural Orthostatic Tachycardia Syndrome After Human Papillomavirus Vaccination in the Vaccine Adverse Event Reporting Systemexternal icon, Association between parent attitudes and receipt of human papillomavirus vaccine in adolescents, Risk of Guillain-Barre Syndrome following quadrivalent human papillomavirus vaccine in the Vaccine Safety Datalink, Maternal and Infant Outcomes After Human Papillomavirus Vaccination in the Periconceptional Period or During Pregnancy, Improving Human Papillomavirus Vaccine Use in an Integrated Health System: Impact of a Provider and Staff Intervention. The Gardasil vaccines also protect against strains 6 and 11. Local Business In poor countries, cervical cancer is a leading cause of female mortality, killing about 300,000 women a year. about half of all adolescents get the full course of HPV shots, no pattern showing that it caused any dangerous or lethal outcomes has been found. Population-level impact and herd effects following the introduction of human papillomavirus vaccination programmes: Updated systematic review and meta-analysis. One other con of the HPV vaccines is that they’re limited in what they do: Who’s most at risk of getting HPV if they’re not vaccinated? CDC recommends HPV vaccination for all boys and girls at ages 11-12 to protect against HPV-related infections and cancers. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. Gee J, Naleway A, Shui I, et al. The safety findings from these pre-licensure studies show that Gardasil 9 has a similar safety profile to Gardasil, an earlier version of the vaccine. These cancers are much more common among men than women: A 2017 study found that the number of American men with HPV-related throat cancer had surpassed the number of American women with cervical cancer. Epub 2019 Jan 16. Along with its needed effects, human papillomavirus vaccine may cause some unwanted effects. British Medical Journal 2013; 347:f5906. external icon Pediatrics. Is one dose of human papillomavirus vaccine as effective as three? Markowitz LM, Gee J, Chesson H, Stokley S. Ten Years of Human Papillomavirus Vaccination in the United States. Each of these vaccines protects against HPV types 16 and 18. Arnheim-Dahlström L, Pasternak B, Svanström H, Sparén P, Hviid A. BMJ. © 2005-2020 Healthline Media a Red Ventures Company. Gee J, Sukumaran L, Weintraub E. Risk of Guillain-Barre Syndrome following quadrivalent human papillomavirus vaccine in the Vaccine Safety Datalinkexternal icon. As recommended by ACIP, people who experienced a severe allergic reaction (e.g., anaphylaxis) to a previous vaccine dose or to a vaccine component, including yeast, should not receive the HPV vaccine. HPV infections that do not go away can cause: Cervical, vaginal, and vulvar cancers (in women) Penile cancer (in men) Anal cancer. [The vaccination in danger?] Reduced prevalence of oral human papillomavirus (HPV) 4 years after bivalent HPV vaccination in a randomized clinical trial in Costa Rica. MMWR. Teens and young adults who start the series at ages 15 through 26 years still need three doses of HPV vaccine. The virus can be transmitted through skin-to-skin contact or through sexual activity. CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. Epub 2016 Apr 10. However, you may pay deductibles and other out-of-pocket fees. Post-licensure safety monitoring of quadrivalent human papillomavirus vaccine in the Vaccine Adverse Event Reporting System (VAERS), 2009-2015external icon. To fully benefit from the vaccine, it’s essential to receive all injections. Human vaccines & immunotherapeutics 2016; 12(6):1406-1417. Medically reviewed by external icon Acad. Vaccines (Basel). Anal and genital warts dropped by 67 percent among teenage girls, by 54 percent among women aged 20 to 24, and by 31 percent among women aged 25 to 29. The HPV vaccine can protect against HPV types 16 and 18, both of which can lead to certain cancers. Markowitz LE, Dunne EF, Saraiya M, et al. 2012 Nov 20;30 Suppl 5:F139-48. Vaccine. Vaccines, like any medicine, can have side effects. Women who are breastfeeding may get the vaccine. In 2014, before Gardasil 9 was licensed by the FDA, its safety was evaluated across seven studies. [Ref], Common (1% to 10%): New medical conditions potentially indicative of systemic autoimmune disorders, Postmarketing reports: Autoimmune diseases[Ref], Common (1% to 10%): Injection site hypersensitivity, Frequency not reported: Allergy to vaccine, Postmarketing reports: Hypersensitivity reactions (including anaphylactic/anaphylactoid reactions, bronchospasm, and urticaria)[Ref], Postmarketing reports: Autoimmune hemolytic anemia, idiopathic thrombocytopenic purpura[Ref], Common (1% to 10%): Dysmenorrhea, vaginal infection, urinary tract infection, Rare (less than 0.1%): Pelvic inflammatory disease, pyelonephritis[Ref], Common (1% to 10%): Rash, urticaria, itching/pruritus, Postmarketing reports: Cellulitis, angioedema, erythema multiforme[Ref], Postmarketing reports: Deep vein thrombosis[Ref]. Women and girls who received Gardasil 9 reported higher rates of swelling and redness where the shot was given than those who received Gardasil. Although HPV often goes away on its own, certain types can cause medical concerns, from genital warts to cervical cancer. Hum Vaccin Immunother. On the relationship between human papilloma virus vaccine and autoimmune diseases. Lipkind HS, Vazquez-Benitez G, Nordin JD et al. Epub 2018 Feb 21. Gardasil 9 targets the most types of HPV out of the three vaccines. Epub 2019 Nov 18. Giuliano AR, Palefsky JM, Goldstone S, et al. 2019 Dec;122(6):e20191808. 2017 Aug; 61(2): 252-258. It’s estimated that 14 million new infections occur…, There are more than 100 types of HPV — some low-risk and some high-risk.

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